Article
Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation.
Genes & development - 15 Jan 1995
Allshire R C, Nimmo E R, Ekwall K, Javerzat J P, Cranston G
Abstract excerpt
The ura4+ gene displays phenotypes consistent with variegated expression when inserted at 11 sites throughout fission yeast centromere 1. An abrupt transition occurs between the zone of centromeric repression and two adjacent expressed sites. Mutations in six genes alleviate repression of the silent-mating type loci and of ura4+ expressed from a site adjacent to the silent locus, mat3-M. Defects at all six loci...
Topics
- Base Sequence
- Centromere
- Chromosomes, Fungal
- Crosses, Genetic
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Heterochromatin
- Meiosis
- Models, Genetic
- Molecular Sequence Data
- Mutation