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Article

Heterochromatin integrity affects chromosome reorganization after centromere dysfunction.

Science (New York, N.Y.) - 22 Aug 2008

Ishii Kojiro, Ogiyama Yuki, Chikashige Yuji, Soejima Saeko, Masuda Fumie, Kakuma Tatsuyuki, Hiraoka Yasushi, Takahashi Kohta

Abstract excerpt

The centromere is essential for the inheritance of genetic information on eukaryotic chromosomes. Epigenetic regulation of centromere identity has been implicated in genome stability, karyotype evolution, and speciation. However, little is known regarding the manner in which centromere dysfunction affects the chromosomal architectures. Here we show that in the fission yeast Schizosaccharomyces pombe, the...

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Identifiers

PMID: 18719285
DOI: 10.1126/science.1158699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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