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Article

Continuous requirement for the Clr4 complex but not RNAi for centromeric heterochromatin assembly in fission yeast harboring a disrupted RITS complex.

PLoS genetics - 28 Oct 2010

Shanker Sreenath, Job Godwin, George Olivia L, Creamer Kevin M, Shaban Alaa, Partridge Janet F

Abstract excerpt

Formation of centromeric heterochromatin in fission yeast requires the combined action of chromatin modifying enzymes and small RNAs derived from centromeric transcripts. Positive feedback mechanisms that link the RNAi pathway and the Clr4/Suv39h1 histone H3K9 methyltransferase complex (Clr-C) re...

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Identifiers

PMID: 21060862
DOI: 10.1371/journal.pgen.1001174
PMCID: PMC2965749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21060862-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Continuous requirement for the Clr4 complex but not RNAi for centromeric heterochromatin assembly in fission yeast harboring a disrupted RITS complex.PMID 21060862Read ↗

Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast.Semantic proximity Read ↗

RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production.Semantic proximity Read ↗

RNAi-mediated targeting of heterochromatin by the RITS complex.Semantic proximity Read ↗

High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin.Semantic proximity Read ↗

Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation.Semantic proximity Read ↗

Splicing factors facilitate RNAi-directed silencing in fission yeast.Semantic proximity Read ↗

Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.Semantic proximity Read ↗

Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly.Semantic proximity Read ↗

Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin.Semantic proximity Read ↗

Centromere silencing and function in fission yeast is governed by the amino terminus of histone H3.Semantic proximity Read ↗

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription.Semantic proximity Read ↗

RNAi-dependent formation of heterochromatin and its diverse functions.Semantic proximity Read ↗

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