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Article

Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast.

The EMBO journal - 28 Aug 2013

Alper Benjamin J, Job Godwin, Yadav Rajesh K, Shanker Sreenath, Lowe Brandon R, Partridge Janet F

Abstract excerpt

Heterochromatin assembly in fission yeast depends on the Clr4 histone methyltransferase, which targets H3K9. We show that the histone deacetylase Sir2 is required for Clr4 activity at telomeres, but acts redundantly with Clr3 histone deacetylase to maintain centromeric heterochromatin. However, Sir2 is critical for Clr4 function during de novo centromeric heterochromatin assembly. We identified new targets of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23771057
DOI: 10.1038/emboj.2013.143
PMCID: PMC3770337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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