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Article

Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast.

The Journal of biological chemistry - 15 Jan 2010

Hou Haitong, Wang Yu, Kallgren Scott P, Thompson James, Yates John R, Jia Songtao

Abstract excerpt

The incorporation of histone variant H2A.Z into nucleosomes plays essential roles in regulating chromatin structure and gene expression. A multisubunit complex containing chromatin remodeling protein Swr1 is responsible for the deposition of H2A.Z in budding yeast and mammals. Here, we show that the JmjC domain protein Msc1 is a novel component of the fission yeast Swr1 complex and is required for Swr1-mediated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Chromosomal Proteins, Non-Histone

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Source

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Identifiers

PMID: 19910462
DOI: 10.1074/jbc.M109.058487
PMCID: PMC2804349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast.PMID 19910462Read ↗

Histone variant H2A.Z functions in sister chromatid cohesion in Saccharomyces cerevisiae.Semantic proximity Read ↗

Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications.Semantic proximity Read ↗

The chromodomain protein Swi6: a key component at fission yeast centromeres.Semantic proximity Read ↗

Centromere silencing and function in fission yeast is governed by the amino terminus of histone H3.Semantic proximity Read ↗

Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange.Semantic proximity Read ↗

Sim4: a novel fission yeast kinetochore protein required for centromeric silencing and chromosome segregation.Semantic proximity Read ↗

Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatin.Semantic proximity Read ↗

A NASP (N1/N2)-related protein, Sim3, binds CENP-A and is required for its deposition at fission yeast centromeres.Semantic proximity Read ↗

NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex.Semantic proximity Read ↗

A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast.Semantic proximity Read ↗

Impact of histone N-terminal domains and linker DNA on H2A.Z deposition by yeast SWR1CSemantic proximity Read ↗

Mutation of histone H3 serine 86 disrupts GATA factor Ams2 expression and precise chromosome segregation in fission yeast.Semantic proximity Read ↗

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