Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.

PLoS genetics - 1 Aug 2018

Yang Jinpu, Sun Siyu, Zhang Shu, Gonzalez Marlyn, Dong Qianhua, Chi Zhongxuan, Chen Yu-Hang, Li Fei

Abstract excerpt

Centromere is a specialized chromatin domain that plays a vital role in chromosome segregation. In most eukaryotes, centromere is surrounded by the epigenetically distinct heterochromatin domain. Heterochromatin has been shown to contribute to centromere function, but the precise role of heterochromatin in centromere specification remains elusive. Centromeres in most eukaryotes, including fission yeast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Centromere
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Segregation

Share to Heterochromatin

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Share to Ubiquitin

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 30089114
DOI: 10.1371/journal.pgen.1007572
PMCID: PMC6101405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation.PMID 30089114Read ↗

An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain.Semantic proximity Read ↗

SAGA DUB-Ubp8 Deubiquitylates Centromeric Histone Variant Cse4.Semantic proximity Read ↗

N-terminal Sumoylation of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis To Prevent Mislocalization to Non-centromeric Chromatin.Semantic proximity Read ↗

The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A.Semantic proximity Read ↗

Heterochromatin integrity affects chromosome reorganization after centromere dysfunction.Semantic proximity Read ↗

N-terminal sumoylation of centromeric histone H3 variant Cse4 regulates its proteolysis to prevent mislocalization to non-centromeric chromatinSemantic proximity Read ↗

Defining the consequences of endogenous genetic variation within a novel family of Schizosaccharomyces pombe heterochromatin nucleating sequences.Semantic proximity Read ↗

A novel role of the N terminus of budding yeast histone H3 variant Cse4 in ubiquitin-mediated proteolysis.Semantic proximity Read ↗

Dual recognition of CENP-A nucleosomes is required for centromere assembly.Semantic proximity Read ↗

N-Terminus Does Not Govern Protein Turnover of Schizosaccharomyces pombe CENP-A.Semantic proximity Read ↗

The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.Semantic proximity Read ↗

The histone fold domain of Cse4 is sufficient for CEN targeting and propagation of active centromeres in budding yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.