Article
MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus.
PLoS genetics - 1 Jan 2013
Deng Yun, Zhao Jian, Sakurai Daisuke, Kaufman Kenneth M, Edberg Jeffrey C, Kimberly Robert P, Kamen Diane L, Gilkeson Gary S, Jacob Chaim O, Scofield R Hal, Langefeld Carl D, Kelly Jennifer A, Ramsey-Goldman Rosalind, Petri Michelle A, Reveille John D, Vilá Luis M, Alarcón Graciela S, Vyse Timothy J, Pons-Estel Bernardo A, Freedman Barry I, Gaffney Patrick M, Sivils Kathy Moser, James Judith A, Gregersen Peter K, Anaya Juan-Manuel, Niewold Timothy B, Merrill Joan T, Criswell Lindsey A, Stevens Anne M, Boackle Susan A, Cantor Rita M, Chen Weiling, Grossman Jeniffer M, Hahn Bevra H, Harley John B, Alarcόn-Riquelme Marta E, Brown Elizabeth E, Tsao Betty P
Abstract excerpt
We previously reported that the G allele of rs3853839 at 3'untranslated region (UTR) of Toll-like receptor 7 (TLR7) was associated with elevated transcript expression and increased risk for systemic lupus erythematosus (SLE) in 9,274 Eastern Asians [P = 6.5×10(-10), odds ratio (OR) (95%CI) = 1.27 (1.17-1.36)]. Here, we conducted trans-ancestral fine-mapping in 13,339 subjects including European Americans, African...
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