Association of a functional IRF7 variant with systemic lupus erythematosus.

doi:10.1002/art.30193

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Article

Association of a functional IRF7 variant with systemic lupus erythematosus.

Arthritis and rheumatism - 1 Mar 2011

Fu Qiong, Zhao Jian, Qian Xiaoxia, Wong Jonathan L H, Kaufman Kenneth M, Yu C Yung, Mok Mo Yin, Harley John B, Guthridge Joel M, Song Yeong Wook, Cho Soo-Kyung, Bae Sang-Cheol, Grossman Jennifer M, Hahn Bevra H, Arnett Frank C, Shen Nan, Tsao Betty P

Abstract excerpt

OBJECTIVE: A previous genome-wide association study conducted in a population of European ancestry identified rs4963128, a KIAA1542 single-nucleotide polymorphism (SNP) 23 kb telomeric to IRF7 (the gene for interferon regulatory factor 7 [IRF-7]), to be strongly associated with systemic lupus erythematosus (SLE). This study was undertaken to investigate whether genetic polymorphism within IRF7 is a risk factor...

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PMID: 21360504
DOI: 10.1002/art.30193
PMCID: PMC3063317

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