Article

MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

2024-01-03

Abstract excerpt

Endosomal single-stranded RNA-sensing Toll-like receptor-7/8 (TLR7/8) plays a pivotal role in inflammation and immune responses and autoimmune diseases. However, the mechanisms underlying the initiation of the TLR7/8-mediated autoimmune signaling remain to be fully elucidated. Here, we demonstrate that miR-574-5p is aberrantly upregulated in tissues of lupus prone mice and in the plasma of lupus patients, with its...

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Literature Corpus work: aeec0209-f407-5d18-bb3d-06380aea04f6
DOI: 10.21203/rs.3.rs-3806898/v1

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