Article
Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus.
Proceedings of the National Academy of Sciences of the United States of America - 7 Sept 2010
Shen Nan, Fu Qiong, Deng Yun, Qian Xiaoxia, Zhao Jian, Kaufman Kenneth M, Wu Yee Ling, Yu C Yung, Tang Yuanjia, Chen Ji-Yih, Yang Wanling, Wong Maida, Kawasaki Aya, Tsuchiya Naoyuki, Sumida Takayuki, Kawaguchi Yasushi, Howe Hwee Siew, Mok Mo Yin, Bang So-Young, Liu Fei-Lan, Chang Deh-Ming, Takasaki Yoshinari, Hashimoto Hiroshi, Harley John B, Guthridge Joel M, Grossman Jennifer M, Cantor Rita M, Song Yeong Wook, Bae Sang-Cheol, Chen Shunle, Hahn Bevra H, Lau Yu Lung, Tsao Betty P
Abstract excerpt
Systemic lupus erythematosus (SLE) is a multisystem, autoimmune disease that predominantly affects women. Previous findings that duplicated Toll-like receptor 7 (Tlr7) promotes lupus-like disease in male BXSB mice prompted us to evaluate TLR7 in human SLE. By using a candidate gene approach, we identified and replicated association of a TLR7 3'UTR SNP, rs3853839 (G/C), with SLE in 9,274 Eastern Asians...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.