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Unveiling the role of TLR9 promoter variants in susceptibility and clinical features of systemic lupus erythematosus.

Lupus - 1 Sept 2026

Soleimani Fatemeh, Karbalaei-Musa Hamidreza, Hajali Mohammad Hossein, Kenarangi Taiebe, Mosallaei Meysam, Ansari Narges

Abstract excerpt

ObjectiveSystemic lupus erythematosus (SLE) is a multifactorial autoimmune disease in which dysregulated nucleic acid sensing and type I interferon responses drive autoantibody production and organ damage. Toll-like receptor 9 (TLR9) regulates these pathways, and promoter variants (rs187084 and rs5743836) may alter TLR9 expression and modulate disease susceptibility and severity. This study evaluated the...

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Case-Control Studies
Complement C3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lupus Erythematosus, Systemic

Promoter Regions, Genetic

Toll-Like Receptor 9

Source

Identifiers

PMID: 42233280
DOI: 10.1177/09612033261458560

Genes

TLR9
C3
CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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