Article
TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study.
Arthritis research & therapy - 11 Mar 2011
Kawasaki Aya, Furukawa Hiroshi, Kondo Yuya, Ito Satoshi, Hayashi Taichi, Kusaoi Makio, Matsumoto Isao, Tohma Shigeto, Takasaki Yoshinari, Hashimoto Hiroshi, Sumida Takayuki, Tsuchiya Naoyuki
Abstract excerpt
INTRODUCTION: The Toll-like receptor 7 (TLR7) gene, encoded on human chromosome Xp22.3, is crucial for type I interferon production. A recent multicenter study in East Asian populations, comprising Chinese, Korean and Japanese participants, identified an association of a TLR7 single-nucleotide polymorphism (SNP) located in the 3' untranslated region (3' UTR), rs3853839, with systemic lupus erythematosus (SLE),...
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