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Article

Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population.

Scientific reports - 21 Jan 2014

Wang Chin-Man, Chang Su-Wei, Wu Yeong-Jian Jan, Lin Jing-Chi, Ho Huei-Huang, Chou Tse-Chih, Yang Bing, Wu Jianming, Chen Ji-Yih

Abstract excerpt

Toll-like receptors (TLRs), as innate immunity sensors, play critical roles in immune responses. Six SNPs of TLR3, TLR7, and TLR8 were genotyped to determine their associations with systemic lupus erythematosus (SLE) and clinical manifestations of SLE. TLR7 SNP rs3853839 was independently associated with SLE susceptibility in females (G vs. C: p = 0.0051). TLR7 rs3853839-G (G vs. C: p = 0.0100) and TLR8...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24445780
DOI: 10.1038/srep03792
PMCID: PMC3896912

Genes

TLR7
TLR8
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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