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Article

Identification of a functional apolipoprotein E promoter polymorphism regulating plasma apolipoprotein E concentration.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2013

Mannila Maria Nastase, Mahdessian Hovsep, Franco-Cereceda Anders, Eggertsen Gösta, de Faire Ulf, Syvänen Ann-Christine, Eriksson Per, Hamsten Anders, van 't Hooft Ferdinand M

Abstract excerpt

OBJECTIVE: There is compelling evidence that the plasma apolipoprotein E (APOE) concentration, in addition to the APOE ε2/ε3/ε4 genotype, influences plasma lipoprotein levels, but the functional genetic variants influencing the plasma APOE concentration have not been identified. APPROACH AND RESULTS: Genome-wide association studies in 2 cohorts of healthy, middle-aged subjects identified the APOE locus as the...

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Source

Identifiers

PMID: 23430611
DOI: 10.1161/ATVBAHA.112.300353

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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