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Article

Genetic landscape of APOE in human longevity revealed by high-throughput sequencing.

Mechanisms of ageing and development - 1 Apr 2016

Ryu Seungjin, Atzmon Gil, Barzilai Nir, Raghavachari Nalini, Suh Yousin

Abstract excerpt

Apolipoprotein E (APOE) gene has been the most replicated longevity-associated gene in humans. Two common APOE alleles are either significantly depleted (ε4 allele) or enriched (ε2 allele) in long-lived individuals as compared to controls. We performed high-throughput sequencing analysis of exons and 2kb proximal promoter of APOE in 450 centenarians and 500 controls of Ashkenazi Jewish decent. We found two common...

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Identifiers

PMID: 26930295
DOI: 10.1016/j.mad.2016.02.010
PMCID: PMC4818712

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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