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Article

APOE/C1/C4/C2 hepatic control region polymorphism influences plasma apoE and LDL cholesterol levels.

Human molecular genetics - 1 Jul 2008

Klos Kathy, Shimmin Lawrence, Ballantyne Christie, Boerwinkle Eric, Clark Andrew, Coresh Josef, Hanis Craig, Liu Kiang, Sayre Scott, Hixson James

Abstract excerpt

We characterized 102 kb of chromosome 19 containing the apolipoprotein (APO) E/C1/C4/C2 cluster and two flanking genes for common DNA variants associated with plasma low-density lipoprotein cholesterol (LDL-C) level. DNA variants were identified by comparing sequences of 48 haploid hybrid cell lines. We genotyped participants (1943 Whites and 2046 African-Americans) of the Coronary Artery Risk Development in...

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Source

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Identifiers

PMID: 18378515
DOI: 10.1093/hmg/ddn101
PMCID: PMC2900905

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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