Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping.

doi:10.1186/s13195-022-00962-4

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Article

Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping.

Alzheimer's research & therapy - 4 Feb 2022

Belloy Michael E, Eger Sarah J, Le Guen Yann, Damotte Vincent, Ahmad Shahzad, Ikram M Arfan, Ramirez Alfredo, Tsolaki Anthoula C, Rossi Giacomina, Jansen Iris E, de Rojas Itziar, Parveen Kayenat, Sleegers Kristel, Ingelsson Martin, Hiltunen Mikko, Amin Najaf, Andreassen Ole, Sánchez-Juan Pascual, Kehoe Patrick, Amouyel Philippe, Sims Rebecca, Frikke-Schmidt Ruth, van der Flier Wiesje M, Lambert Jean-Charles, He Zihuai, Han Summer S, Napolioni Valerio, Greicius Michael D

Abstract excerpt

BACKGROUND: Genetic variants within the APOE locus may modulate Alzheimer's disease (AD) risk independently or in conjunction with APOE*2/3/4 genotypes. Identifying such variants and mechanisms would importantly advance our understanding of APOE pathophysiology and provide critical guidance for AD therapies aimed at APOE. The APOE locus however remains relatively poorly understood in AD, owing to multiple...

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PMID: 35120553
DOI: 10.1186/s13195-022-00962-4
PMCID: PMC8815198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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