Article
Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels.
Human mutation - 1 Jan 1994
de Knijff P, van den Maagdenberg A M, Frants R R, Havekes L M
Abstract excerpt
Apolipoprotein E (apoE) is one of the major protein constituents of chylomicron and very-low-density lipoprotein (VLDL) remnants and plays a central role as a ligand in the receptor-mediated uptake of these particles by the liver. Including the most common variant, apoE3, 30 apoE variants have been characterized. At present, 14 apoE variants have been found to be associated with familial dysbetalipoproteinemia, a...
Topics
- Alleles
- Amino Acid Sequence
- Apolipoproteins E
- Base Sequence
- DNA
- Female
- Gene Frequency
- Genetic Variation
- Humans
- Hyperlipidemias
- Hyperlipoproteinemia Type III