Genetic and Mechanistic Insights into the Modulation of Circulating Lipoprotein (a) Concentration by Apolipoprotein E Isoforms.

doi:10.1007/s11883-022-01016-8

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Article

Genetic and Mechanistic Insights into the Modulation of Circulating Lipoprotein (a) Concentration by Apolipoprotein E Isoforms.

Current atherosclerosis reports - 1 Jun 2022

Chemello Kévin, Blom Dirk J, Marais A David, Lambert Gilles, Blanchard Valentin

Abstract excerpt

PURPOSE OF REVIEW: Lipoprotein (a) [Lp(a)] is a highly atherogenic lipoprotein species. A unique feature of Lp(a) is the strong genetic determination of its concentration. The LPA gene is responsible for up to 90% of the variance in Lp(a), but other genes also have an impact. RECENT FINDINGS: Genome-wide associations studies indicate that the APOE gene, encoding apolipoprotein E (apoE), is the second most...

Topics

Adult
Apolipoproteins E
Genotype
Humans
Hyperlipoproteinemia Type III
Lipoprotein(a)
Protein Isoforms

Source

Open in PubMed

Identifiers

PMID: 35355214
DOI: 10.1007/s11883-022-01016-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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