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Article

Effect of COMT val158met genotype on cognition and personality.

European psychiatry : the journal of the Association of European Psychiatrists - 1 Sept 2008

Sheldrick A J, Krug A, Markov V, Leube D, Michel T M, Zerres K, Eggermann T, Kircher T

Abstract excerpt

The gene encoding catechol-O-methyltransferase (COMT), an enzyme which regulates prefrontal cortex dopamine, contains a common functional single nucleotide polymorphism (val158met, rs4680G/A), which accounts for part of the interindividual variance in performance during working memory tasks and also predicts personality traits. We examined the relationship between the val158met polymorphism and cognitive function...

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Source

Identifiers

PMID: 18755576
DOI: 10.1016/j.eurpsy.2008.05.002

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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