Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of association between COMT and working memory in a population-based cohort of healthy young adults.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2013

Wardle Margaret C, de Wit Harriet, Penton-Voak Ian, Lewis Glyn, Munafò Marcus R

Abstract excerpt

The Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene is an important regulator of dopamine in the prefrontal cortex, an area critical to working memory. Working memory deficits are present in several psychiatric disorders, and there is wide variation in working memory capacity in the normal population. Association studies of COMT and working memory in healthy volunteers have yielded...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Genetic Association Studies

Share to Memory, Short-Term

Share to Psychomotor Performance

Share to Reaction Time

Share to Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 23337869
DOI: 10.1038/npp.2013.24
PMCID: PMC3656369

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of association between COMT and working memory in a population-based cohort of healthy young adults.PMID 23337869Read ↗

Putative role of the COMT gene polymorphism (Val158Met) on verbal working memory functioning in a healthy population.Semantic proximity Read ↗

Effects of two dopamine-modulating genes (DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers.Semantic proximity Read ↗

COMT rs4680 Met is not always the 'smart allele': Val allele is associated with better working memory and larger hippocampal volume in healthy Chinese.Semantic proximity Read ↗

Catechol O-methyltransferase variants and cognitive performance in schizophrenia and bipolar disorder versus controls.Semantic proximity Read ↗

COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals.Semantic proximity Read ↗

COMT polymorphism and memory dedifferentiation in old age.Semantic proximity Read ↗

Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism.Semantic proximity Read ↗

COMT Val158Met Genotype and Individual Differences in Executive Function in Healthy Adults.Semantic proximity Read ↗

No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study.Semantic proximity Read ↗

Gender effects of the COMT Val 158 Met genotype on verbal fluency in healthy adults.Semantic proximity Read ↗

Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.Semantic proximity Read ↗

Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.