Stress-related methylation of the catechol-O-methyltransferase Val 158 allele predicts human prefrontal cognition and activity.

doi:10.1523/JNEUROSCI.6631-10.2011

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Article

Stress-related methylation of the catechol-O-methyltransferase Val 158 allele predicts human prefrontal cognition and activity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 May 2011

Ursini Gianluca, Bollati Valentina, Fazio Leonardo, Porcelli Annamaria, Iacovelli Luisa, Catalani Assia, Sinibaldi Lorenzo, Gelao Barbara, Romano Raffaella, Rampino Antonio, Taurisano Paolo, Mancini Marina, Di Giorgio Annabella, Popolizio Teresa, Baccarelli Andrea, De Blasi Antonio, Blasi Giuseppe, Bertolino Alessandro

Abstract excerpt

DNA methylation at CpG dinucleotides is associated with gene silencing, stress, and memory. The catechol-O-methyltransferase (COMT) Val(158) allele in rs4680 is associated with differential enzyme activity, stress responsivity, and prefrontal activity during working memory (WM), and it creates a CpG dinucleotide. We report that methylation of the Val(158) allele measured from peripheral blood mononuclear cells...

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PMID: 21543598
DOI: 10.1523/JNEUROSCI.6631-10.2011
PMCID: PMC6632869

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