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Article

Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics.

NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics - 1 Jan 2006

Diaz-Asper Catherine M, Weinberger Daniel R, Goldberg Terry E

Abstract excerpt

Catechol-O-methyltransferase (COMT) is a gene involved in the degradation of dopamine and may both increase susceptibility to develop schizophrenia and affect neuronal functions involved in working memory. A common variant of the COMT gene (val(108/158)met) has been widely reported to affect pre-frontally mediated working memory function, with the high-activity val allele associated with poorest performance...

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Source

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Identifiers

PMID: 16490416
DOI: 10.1016/j.nurx.2005.12.010
PMCID: PMC3593358

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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