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Article

G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice.

Biochemical and biophysical research communications - 27 Mar 2015

Shimizu Akinori, Mito Takayuki, Hashizume Osamu, Yonekawa Hiromichi, Ishikawa Kaori, Nakada Kazuto, Hayashi Jun-Ichi

Abstract excerpt

We previously generated mito-mice-tRNA(Lys7731) as a model for primary prevention of mitochondrial diseases. These mice harbour a G7731A mtDNA mutation in the tRNA(Lys) gene, but express only muscle weakness and short body length by four months. Here, we examined the effects of their aging on metabolic and histologic features. Unlike young mito-mice-tRNA(Lys7731), aged mito-mice-tRNA(Lys7731) developed muscle...

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PMID: 25721669
DOI: 10.1016/j.bbrc.2015.02.070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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