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Article

Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders.

Biochemical and biophysical research communications - 24 Jan 2015

Mito Takayuki, Ishizaki Hikari, Suzuki Michiko, Morishima Hitomi, Ota Azusa, Ishikawa Kaori, Nakada Kazuto, Maeno Akiteru, Shiroishi Toshihiko, Hayashi Jun-Ichi

Abstract excerpt

The spectra of phenotypes associated with aging and mitochondrial diseases sometimes appear to overlap with each other. We used aged mice and a mouse model of mitochondrial diseases (transmitochondrial mito-miceΔ with deleted mtDNA) to study whether premature aging phenotypes observed in mtDNA mutator mice are associated with aging or mitochondrial diseases. Here, we provide convincing evidence that all the mice...

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PMID: 25511702
DOI: 10.1016/j.bbrc.2014.12.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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