Article
Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders.
Biochemical and biophysical research communications - 24 Jan 2015
Mito Takayuki, Ishizaki Hikari, Suzuki Michiko, Morishima Hitomi, Ota Azusa, Ishikawa Kaori, Nakada Kazuto, Maeno Akiteru, Shiroishi Toshihiko, Hayashi Jun-Ichi
Abstract excerpt
The spectra of phenotypes associated with aging and mitochondrial diseases sometimes appear to overlap with each other. We used aged mice and a mouse model of mitochondrial diseases (transmitochondrial mito-miceΔ with deleted mtDNA) to study whether premature aging phenotypes observed in mtDNA mu...
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