Article
Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.
Cell metabolism - 1 Aug 2009
Edgar Daniel, Shabalina Irina, Camara Yolanda, Wredenberg Anna, Calvaruso Maria Antonietta, Nijtmans Leo, Nedergaard Jan, Cannon Barbara, Larsson Nils-Göran, Trifunovic Aleksandra
Abstract excerpt
The mtDNA mutator mice have high levels of point mutations and linear deletions of mtDNA causing a progressive respiratory chain dysfunction and a premature aging phenotype. We have now performed molecular analyses to determine the mechanism whereby these mtDNA mutations impair respiratory chain function. We report that mitochondrial protein synthesis is unimpaired in mtDNA mutator mice consistent with the...
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