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Article

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

Cell metabolism - 1 Aug 2009

Edgar Daniel, Shabalina Irina, Camara Yolanda, Wredenberg Anna, Calvaruso Maria Antonietta, Nijtmans Leo, Nedergaard Jan, Cannon Barbara, Larsson Nils-Göran, Trifunovic Aleksandra

Abstract excerpt

The mtDNA mutator mice have high levels of point mutations and linear deletions of mtDNA causing a progressive respiratory chain dysfunction and a premature aging phenotype. We have now performed molecular analyses to determine the mechanism whereby these mtDNA mutations impair respiratory chain...

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Source

Identifiers

PMID: 19656491
DOI: 10.1016/j.cmet.2009.06.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19656491-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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