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Article

Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging.

Current opinion in genetics & development - 1 Jun 2016

Hayashi Jun-Ichi, Hashizume Osamu, Ishikawa Kaori, Shimizu Akinori

Abstract excerpt

The mitochondria theory of aging proposes that accumulation of mitochondrial DNA (mtDNA) with pathogenic mutations, and the resultant respiration defects, are responsible not only for mitochondrial diseases but also for aging and age-associated disorders, including tumor development. This theory is partly supported by results obtained from our transmitochondrial mice (mito-mice), which harbour mtDNA with...

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Identifiers

PMID: 27078865
DOI: 10.1016/j.gde.2016.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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