Article
Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.
Nature - 19 Sept 2013
Ross Jaime M, Stewart James B, Hagström Erik, Brené Stefan, Mourier Arnaud, Coppotelli Giuseppe, Freyer Christoph, Lagouge Marie, Hoffer Barry J, Olson Lars, Larsson Nils-Göran
Abstract excerpt
Ageing is due to an accumulation of various types of damage, and mitochondrial dysfunction has long been considered to be important in this process. There is substantial sequence variation in mammalian mitochondrial DNA (mtDNA), and the high mutation rate is counteracted by different mechanisms that decrease maternal transmission of mutated mtDNA. Despite these protective mechanisms, it is becoming increasingly...
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