Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transmitochondrial mice as models for mitochondrial DNA-based diseases.

Experimental animals - 1 Jan 2011

Nakada Kazuto, Hayashi Jun-Ichi

Abstract excerpt

Mitochondrial genome (mtDNA) mutations and the resultant mitochondrial respiratory abnormalities are associated with a wide variety of disorders, such as mitochondrial diseases, neurodegenerative diseases, diabetes, and cancer, as well as aging. Generation of model animals carrying mutant mtDNAs is important for understanding the pathophysiological mechanisms of the mtDNA-based diseases. We have succeeded in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to DNA, Mitochondrial
Share to Embryonic Stem Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Infertility, Male

Share to Memory Disorders

Share to Mitochondrial Diseases

Share to Nuclear Transfer Techniques

Share to Zygote

Source

Identifiers

PMID: 22041279
DOI: 10.1538/expanim.60.421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transmitochondrial mice as models for mitochondrial DNA-based diseases.PMID 22041279Read ↗

Reverse genetic studies of mitochondrial DNA-based diseases using a mouse model.Semantic proximity Read ↗

[Model mouse for mitochondrial DNA-based diseases].Semantic proximity Read ↗

Attempts to understand the mechanisms of mitochondrial diseases: The reverse genetics of mouse models for mitochondrial disease.Semantic proximity Read ↗

Concise Review: Heteroplasmic Mitochondrial DNA Mutations and Mitochondrial Diseases: Toward iPSC-Based Disease Modeling, Drug Discovery, and Regenerative Therapeutics.Semantic proximity Read ↗

The pathophysiology of mitochondrial disease as modeled in the mouse.Semantic proximity Read ↗

[Mouse models for mitochondrial DNA-based diseases].Semantic proximity Read ↗

[Mitochondrial DNA-based disease model mice].Semantic proximity Read ↗

Current progress with mammalian models of mitochondrial DNA disease.Semantic proximity Read ↗

Clinical Approaches for Mitochondrial Diseases.Semantic proximity Read ↗

G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice.Semantic proximity Read ↗

Mitochondrial DNA with a large-scale deletion causes two distinct mitochondrial disease phenotypes in mice.Semantic proximity Read ↗

Mouse models for mitochondrial disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.