Article
Transmitochondrial mice as models for mitochondrial DNA-based diseases.
Experimental animals - 1 Jan 2011
Nakada Kazuto, Hayashi Jun-Ichi
Abstract excerpt
Mitochondrial genome (mtDNA) mutations and the resultant mitochondrial respiratory abnormalities are associated with a wide variety of disorders, such as mitochondrial diseases, neurodegenerative diseases, diabetes, and cancer, as well as aging. Generation of model animals carrying mutant mtDNAs is important for understanding the pathophysiological mechanisms of the mtDNA-based diseases. We have succeeded in...
Topics
- Animals
- DNA, Mitochondrial
- Disease Models, Animal
- Embryonic Stem Cells
- Humans
- Infertility, Male
- Male
- Memory Disorders
- Mice
- Mitochondrial Diseases
- Mutation
- Nuclear Transfer Techniques