Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transition of a microRNA from repressing to activating translation depending on the extent of base pairing with the target.

PloS one - 1 Jan 2013

Saraiya Ashesh A, Li Wei, Wang Ching C

Abstract excerpt

MicroRNAs are major post-transcriptional regulators of gene expression. Here we show in the ancient protozoan Giardia lamblia a snoRNA-derived 26-nucleotide microRNA, miR3, which represses the translation of histone H2A mRNA containing an imperfect target but enhances translation when the target is made fully complementary. A stepwise mutational analysis of the fully complementary target showed that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Base Pairing
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Giardia lamblia

Share to Histones

Share to MicroRNAs

Share to Protein Biosynthesis

Share to RNA, Small Nucleolar

Source

Open in PubMed Open full text

Identifiers

PMID: 23405193
DOI: 10.1371/journal.pone.0055672
PMCID: PMC3565978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transition of a microRNA from repressing to activating translation depending on the extent of base pairing with the target.PMID 23405193Read ↗

Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNASemantic proximity Read ↗

Functional and evolutionary significance of human microRNA seed region mutations.Semantic proximity Read ↗

Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis.Semantic proximity Read ↗

Structural basis for differential targeting properties of small RNAs in plants and animalsSemantic proximity Read ↗

Evolutionary dynamics of microRNA target sites across vertebrate evolution.Semantic proximity Read ↗

Recapitulation of short RNA-directed translational gene silencing in vitro.Semantic proximity Read ↗

The Integrator complex regulates microRNA abundance through RISC loadingSemantic proximity Read ↗

Molecular dynamics simulations of Ago silencing complexes reveal a large repertoire of admissible 'seed-less' targets.Semantic proximity Read ↗

The terminal loop region controls microRNA processing by Drosha and Dicer.Semantic proximity Read ↗

GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis.Semantic proximity Read ↗

A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA.Semantic proximity Read ↗

A role for the P-body component GW182 in microRNA function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.