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Article

Functional and evolutionary significance of human microRNA seed region mutations.

PloS one - 1 Jan 2014

Hill Christopher G, Jabbari Neda, Matyunina Lilya V, McDonald John F

Abstract excerpt

MicroRNAs have emerged in recent years as important regulators of cell function in both normal and diseased cells. MiRNAs coordinately regulate large suites of target genes by mRNA degradation and/or translational inhibition. The mRNA target specificities of miRNAs in animals are primarily encoded within a 7 nt "seed region" mapping to positions 2-8 at the molecule's 5' end. We here combine computational analyses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25501359
DOI: 10.1371/journal.pone.0115241
PMCID: PMC4264867

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