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Article

Molecular dynamics simulations of Ago silencing complexes reveal a large repertoire of admissible 'seed-less' targets.

Scientific reports - 1 Jan 2012

Xia Zhen, Clark Peter, Huynh Tien, Loher Phillipe, Zhao Yue, Chen Huang-Wen, Ren Pengyu, Rigoutsos Isidore, Zhou Ruhong

Abstract excerpt

To better understand the recognition mechanism of RISC and the repertoire of guide-target interactions we introduced G:U wobbles and mismatches at various positions of the microRNA (miRNA) 'seed' region and performed all-atom molecular dynamics simulations of the resulting Ago-miRNA:mRNA ternary complexes. Our simulations reveal that many modifications, including combinations of multiple G:U wobbles and...

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Identifiers

PMID: 22888400
DOI: 10.1038/srep00569
PMCID: PMC3415692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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