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Article

Evolutionary dynamics of microRNA target sites across vertebrate evolution.

PLoS genetics - 1 Feb 2020

Simkin Alfred, Geissler Rene, McIntyre Alexa B R, Grimson Andrew

Abstract excerpt

MicroRNAs (miRNAs) control the abundance of the majority of the vertebrate transcriptome. The recognition sequences, or target sites, for bilaterian miRNAs are found predominantly in the 3' untranslated regions (3'UTRs) of mRNAs, and are amongst the most highly conserved motifs within 3'UTRs. However, little is known regarding the evolutionary pressures that lead to loss and gain of such target sites. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32012152
DOI: 10.1371/journal.pgen.1008285
PMCID: PMC7018135

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