Article
Recapitulation of short RNA-directed translational gene silencing in vitro.
Molecular cell - 19 May 2006
Wang Bingbing, Love Tara M, Call Matthew E, Doench John G, Novina Carl D
Abstract excerpt
microRNAs (miRNAs) are a large class of endogenous short RNAs that repress gene expression. Many miRNAs are conserved throughout evolution, and dysregulation of miRNA pathways has been correlated with an increasing number of human diseases. In animals, miRNAs typically bind to the 3' untranslated region (3'UTR) of target mRNAs with imperfect sequence complementarity and repress translation. Despite their...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.