Article

The Integrator complex regulates microRNA abundance through RISC loading

2021-09-21

Abstract excerpt

MicroRNA (miRNA) homeostasis is crucial for the post-transcriptional regulation of their target genes and miRNA dysregulation has been linked to multiple diseases, including cancer. The molecular mechanisms underlying miRNA biogenesis from processing of primary miRNA transcripts to formation of mature miRNA duplex are well understood 1-4 . Loading of miRNA duplex into members of the Argonaute (Ago) protein family...

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Literature Corpus work: 69ef0230-5ea5-585b-b345-36fd74e1b17e
DOI: 10.1101/2021.09.21.461113

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