Article
A role for the P-body component GW182 in microRNA function.
Nature cell biology - 1 Dec 2005
Liu Jidong, Rivas Fabiola V, Wohlschlegel James, Yates John R, Parker Roy, Hannon Gregory J
Abstract excerpt
In animals, the majority of microRNAs regulate gene expression through the RNA interference (RNAi) machinery without inducing small-interfering RNA (siRNA)-directed mRNA cleavage. Thus, the mechanisms by which microRNAs repress their targets have remained elusive. Recently, Argonaute proteins, which are key RNAi effector components, and their target mRNAs were shown to localize to cytoplasmic foci known as...
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