Article

Human Argonaute2 and Argonaute3 are catalytically activated by different lengths of guide RNA

2020-07-17

Abstract excerpt

RNA interfering is a eukaryote-specific gene silencing by 20∼23 nucleotide (nt) microRNAs and small interfering RNAs that recruit Argonaute proteins to complementary RNAs for degradation. In humans, Argonaute2 (AGO2) has been known as the only slicer while Argonaute3 (AGO3) barely cleaves RNAs. Therefore, the intrinsic slicing activity of AGO3 remains controversial and a long-standing question. Here, we report 14-...

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Literature Corpus work: b3b4a405-3749-5805-8ac0-25935cb7a0ae
DOI: 10.1101/2020.07.16.207720

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