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Article

GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis.

PLoS genetics - 1 Dec 2016

Jannot Guillaume, Michaud Pascale, Quévillon Huberdeau Miguel, Morel-Berryman Louis, Brackbill James A, Piquet Sandra, McJunkin Katherine, Nakanishi Kotaro, Simard Martin J

Abstract excerpt

MicroRNAs and Argonaute form the microRNA induced silencing complex or miRISC that recruits GW182, causing mRNA degradation and/or translational repression. Despite the clear conservation and molecular significance, it is unknown if miRISC-GW182 interaction is essential for gene silencing during animal development. Using Caenorhabditis elegans to explore this question, we examined the relationship and effect on...

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PMID: 27935964
DOI: 10.1371/journal.pgen.1006484
PMCID: PMC5147811

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