Structure function analysis of in vitro mutated CD4 and major histocompatibility complex class II gene products.

Abstract excerpt

The Class II major histocompatibility molecules are implicated in the initiation of antigen-driven autoimmune responses by CD4-positive T cells. In order to study the structure and function of CD4 and MHC Class II molecules, strategies were developed with the intent of generating secreted forms of these molecules by in vitro mutagenesis of the respective genes. A full length cDNA encoding an expressible human CD4...

Topics

• Animals
• Base Sequence
• CD4 Antigens
• Histocompatibility Antigens Class II
• Humans
• Mice
• Molecular Sequence Data
• Mutation
• Structure-Activity Relationship
• Transfection