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Article

Failure of cell surface expression of a class I major histocompatibility antigen caused by somatic point mutation.

Transplantation - 1 Apr 1990

Zeff R A, Nakagawa M, Mashimo H, Gopas J, Nathenson S G

Abstract excerpt

The ability to down-regulate major histocompatibility complex class I antigen expression on allografts prior to transplantation would be expected to improve their survival in immunocompetent recipients. In order to identify genetic mechanisms that mediate attenuation of MHC class I antigen expression, we have begun characterizing H-2Kb surface null somatic cell variants derived from an H-2 heterozygous tumor cell...

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Identifiers

PMID: 2326874
DOI: 10.1097/00007890-199004000-00029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Failure of cell surface expression of a class I major histocompatibility antigen caused by somatic point mutation.PMID 2326874Read ↗

Molecular immunology of allograft rejection: insights from MHC mutants and crystal structure.Semantic proximity Read ↗

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The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.Semantic proximity Read ↗

Mutation at amino acid position 133 of H-2Dd prevents beta 2m association and immune recognition but not surface expression.Semantic proximity Read ↗

Defective presentation of endogenous antigen by a cell line expressing class I molecules.Semantic proximity Read ↗

In vivo antagonism of a T cell response by an endogenously expressed ligand.Semantic proximity Read ↗

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