Article
Failure of cell surface expression of a class I major histocompatibility antigen caused by somatic point mutation.
Transplantation - 1 Apr 1990
Zeff R A, Nakagawa M, Mashimo H, Gopas J, Nathenson S G
Abstract excerpt
The ability to down-regulate major histocompatibility complex class I antigen expression on allografts prior to transplantation would be expected to improve their survival in immunocompetent recipients. In order to identify genetic mechanisms that mediate attenuation of MHC class I antigen expres...
Topics
- Animals
- Antigens, Surface
- Base Sequence
- Cell Line
- Cloning, Molecular
- Cytotoxicity, Immunologic
- Fibroblasts
- Gene Expression Regulation
- H-2 Antigens
- Mice
- Molecular Sequence Data
- Mutation
- T-Lymphocytes, Cytotoxic
- Transfection