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Article

Biosynthesis and intracellular transport of MHC class II molecules associated with a mutated, glycosaminoglycan-negative invariant chain.

Molecular immunology - 1 May 1990

Simonis S, Miller J, Cullen S E

Abstract excerpt

The MHC Class II molecular complex is composed of polymorphic alpha and beta chains and a non-polymorphic "invariant" chain (Ii) that can be converted to a chondroitin sulfate proteoglycan. To determine whether the proteoglycan form of invariant chain (Ii-CS) had a role in the expression of the Class II complex, we studied the biosynthetic fate of alpha-beta in cells transfected either with normal Ii cDNA or with...

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Source

Identifiers

PMID: 2366758
DOI: 10.1016/0161-5890(90)90165-v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Biosynthesis and intracellular transport of MHC class II molecules associated with a mutated, glycosaminoglycan-negative invariant chain.PMID 2366758Read ↗

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The chondroitin sulfate form of invariant chain trimerizes with conventional invariant chain and these complexes are rapidly transported from the trans-Golgi network to the cell surface.Semantic proximity Read ↗

Mutations in specific I-A(k) alpha(2) and beta(2) domain residues affect surface expression.Semantic proximity Read ↗

Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation.Semantic proximity Read ↗

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Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells.Semantic proximity Read ↗

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