Article
High level expression in Chinese hamster ovary cells of soluble forms of CD4 T lymphocyte glycoprotein including glycosylation variants.
The Journal of biological chemistry - 25 Jun 1990
Davis S J, Ward H A, Puklavec M J, Willis A C, Williams A F, Barclay A N
Abstract excerpt
The CD4 cell surface antigen is of interest as a marker of T lymphocytes that recognize foreign antigens in the context of MHC Class II antigen, as a receptor for the human immunodeficiency virus (HIV) and as a member of the immunoglobulin superfamily (IgSF) with four Ig-like domains present in the extracellular domain. In order to produce large amounts of soluble CD4 for x-ray crystallography and other molecular...
Topics
- Amino Acid Sequence
- Animals
- CD4 Antigens
- Cell Line
- Cricetinae
- Cricetulus
- Female
- Gene Expression
- Genes, MHC Class II
- Genetic Variation
- Glycopeptides