Article
Structural analysis of the CD2 T lymphocyte antigen by site-directed mutagenesis to introduce a disulphide bond into domain 1.
Protein engineering - 1 Nov 1993
Gray F, Cyster J G, Willis A C, Barclay A N, Williams A F
Abstract excerpt
Many proteins have been predicted to contain domains with immunoglobulin-like folds and hence to be members of the immunoglobulin superfamily (IgSF). However, several members lack the Cys residues capable of forming the disulphide bond that forms a characteristic bridge between the beta sheets in the Ig fold, e.g. domain 1 of the lymphocyte antigen CD2. The assignment of beta strands in CD2 by sequence analysis...
Topics
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Base Sequence
- CD2 Antigens
- CHO Cells
- Cricetinae
- Disulfides
- Epitopes