Article
Functional and molecular characterization of I-A kappa beta mutants is consistent with the predicted three dimensional structure of class II MHC molecules.
Molecular immunology - 1 Jul 1990
Brown M A, Griffith I J, Glimcher L H
Abstract excerpt
Class II MHC (Ia) molecules have been shown to be critical as restriction elements in the T helper/inducer cell recognition of antigen. Efforts to determine the role of allelic variation in MHC restricted antigen presentation have included the use of serologically selected mutants to correlate st...
Topics
- Amino Acid Sequence
- Animals
- Antigen-Presenting Cells
- Binding Sites
- Cell Line
- Histocompatibility Antigens Class II
- Hybridomas
- In Vitro Techniques
- Mice
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Structure-Activity Relationship
- T-Lymphocytes