Article
Analysis of the H-2Kbm8 mutant: correlation of structure with function.
Molecular immunology - 1 Jul 1991
Pfaffenbach G M, Uehara H, Geliebter J, Nathenson S G, Schulze D H
Abstract excerpt
The gene for H-2K class I major histocompatibility antigen on the bm8 variant was cloned and the DNA sequence compared with the parental gene. Sequence analysis demonstrated that seven nucleotides were changed with respect to the parental gene sequence spanning 24 nucleotides. These changes represent an alteration of four amino acids from the parent protein. As this mutation occurred in a single generation, a...
Topics
- Animals
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- DNA
- H-2 Antigens
- Histocompatibility Antigens Class I
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation