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Article

Asynchronous replication of homologous loci on human active and inactive X chromosomes.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990

Schmidt M, Migeon B R

Abstract excerpt

The two X chromosomes in mammalian females replicate asynchronously, the inactive later than the active one. Using BrdUrd-sensitive restriction and UV irradiation to identify newly synthesized DNA directly on Southern blots, and restriction fragment length differences to discriminate alleles on active and inactive human X chromosomes, we examined the replication of hypoxanthine phosphoribosyltransferase (HPRT)...

Topics

Alleles
Animals
Blotting, Southern
Bromodeoxyuridine
Cell Line
DNA
DNA Probes
DNA Replication
Female
Humans
Hybrid Cells
Hypoxanthine Phosphoribosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interphase

Mice

Mitosis

Restriction Mapping

X Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 2339112
DOI: 10.1073/pnas.87.10.3685
PMCID: PMC53967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2339112-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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