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Article

Asynchronous replication of homologous loci on human active and inactive X chromosomes.

Proceedings of the National Academy of Sciences of the United States of America - 1 May 1990

Schmidt M, Migeon B R

Abstract excerpt

The two X chromosomes in mammalian females replicate asynchronously, the inactive later than the active one. Using BrdUrd-sensitive restriction and UV irradiation to identify newly synthesized DNA directly on Southern blots, and restriction fragment length differences to discriminate alleles on active and inactive human X chromosomes, we examined the replication of hypoxanthine phosphoribosyltransferase (HPRT)...

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Identifiers

PMID: 2339112
DOI: 10.1073/pnas.87.10.3685
PMCID: PMC53967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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