Reverse replication timing for the XIST gene in human fibroblasts.

doi:10.1093/hmg/4.5.813

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Article

Reverse replication timing for the XIST gene in human fibroblasts.

Human molecular genetics - 1 May 1995

Hansen R S, Canfield T K, Gartler S M

Abstract excerpt

The timing of DNA replication appears to be an important epigenetic regulator of gene expression during development. Replication of active genes in expressing tissues occurs earlier than does replication of their inactive counterparts in nonexpressing tissues. This pattern is also observed for active and inactive alleles present in the same cell, as exemplified by genes subject to X chromosome inactivation in...

Topics

Alleles
Base Sequence
Cells, Cultured
DNA Primers
DNA Replication
Dosage Compensation, Genetic
Female
Fibroblasts
Gene Expression Regulation
HeLa Cells
Humans
Hybrid Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Molecular Sequence Data

Polymerase Chain Reaction

S Phase

Time Factors

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 7633440
DOI: 10.1093/hmg/4.5.813

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7633440-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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