Article
Multiple in vivo footprints are specific to the active allele of the X-linked human hypoxanthine phosphoribosyltransferase gene 5' region: implications for X chromosome inactivation.
Molecular and cellular biology - 1 Dec 1992
Hornstra I K, Yang T P
Abstract excerpt
Dosage compensation of X-linked genes in male and female mammals is accomplished by random inactivation of one X chromosome in each female somatic cell. As a result, a transcriptionally active allele and a transcriptionally inactive allele of most X-linked genes reside within each female nucleus....
Topics
- Alleles
- Animals
- Base Sequence
- Cell Line
- Cricetinae
- DNA
- Dosage Compensation, Genetic
- Genetic Linkage
- HeLa Cells
- Humans
- Hybrid Cells
- Hypoxanthine Phosphoribosyltransferase
- Male
- Mice
- Molecular Sequence Data
- Polymerase Chain Reaction
- X Chromosome