Article
Chromosomal coordination and differential structure of asynchronous replicating regions.
Nature communications - 15 Feb 2021
Blumenfeld Britny, Masika Hagit, Farago Marganit, Yehuda Yishai, Halaseh Lamia, Vardi Oriya, Rapoport Rachel, Levin-Klein Rena, Cedar Howard, Bergman Yehudit, Simon Itamar
Abstract excerpt
Stochastic asynchronous replication timing (AS-RT) is a phenomenon in which the time of replication of each allele is different, and the identity of the early allele varies between cells. By taking advantage of stable clonal pre-B cell populations derived from C57BL6/Castaneous mice, we have mapped the genome-wide AS-RT loci, independently of genetic differences. These regions are characterized by differential...
Topics
- Alleles
- Animals
- Bone Marrow Cells
- Chromatin
- Clone Cells
- Crosses, Genetic
- DNA Replication Timing
- Embryo, Mammalian
- Embryonic Development
- Epigenesis, Genetic
- Female
- Genetic Loci
- Genome