The replication rate of human hematopoietic stem cells in vivo.

doi:10.1182/blood-2010-08-303537

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The replication rate of human hematopoietic stem cells in vivo.

Blood - 28 Apr 2011

Catlin Sandra N, Busque Lambert, Gale Rosemary E, Guttorp Peter, Abkowitz Janis L

Abstract excerpt

Hematopoietic stem cells (HSCs) replicate (self-renew) to create 2 daughter cells with capabilities equivalent to their parent, as well as differentiate, and thus can both maintain and restore blood cell production. Cell labeling with division-sensitive markers and competitive transplantation studies have been used to estimate the replication rate of murine HSCs in vivo. However, these methods are not feasible in...

Topics

Adolescent
Adult
Aging
Anemia, Aplastic
Animals
Bone Marrow Diseases
Bone Marrow Failure Disorders
Cats
Cell Division
Child
Child, Preschool
Computer Simulation
Cord Blood Stem Cell Transplantation
Female

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hematopoiesis

Hematopoietic Stem Cells

Hemoglobinuria, Paroxysmal

Humans

Source

Open in PubMed Open full text

Identifiers

PMID: 21343613
DOI: 10.1182/blood-2010-08-303537
PMCID: PMC3099568

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.